Nnkleine levin syndrome pdf

Kleinelevin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleinelevin syndrome are male. Kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. Kleine levin syndrome, sometimes referred to as rip van winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence. Kleinelevin syndrome kls is a sleep disorder that is characterized by recurring episodes of excessive sleep. Treatments for kleinelevin syndrome stanford health care. Symptoms occur as episodes, typically lasting a few days to a few weeks. Some aspects of the disease can be managed with medication, such as stimulants to combat the eds, but this is most effective only once the episodes have already decreased in severity. My son and kleinelevin syndrome the sleeping beauty. Kleinelevin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. Kleinelevin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world. Kleine levin syndrome was first described by kleine in 1925 and elaborated on by levin in 1936, but it was critchley and hoffman who further defined the syndrome in 1942 and gave it its eponym. These episodes usually last for a few days to a few weeks. Most often an affliction that affects adolescent males, the episodes may come out of nowhere and affect your loved one for a few days or a few weeks.

It is characterized by recurrent episodes, lasting days to weeks, of severe hypersomnia, cognitive impairment, major apathy and derealisation. All books are in clear copy here, and all files are secure so dont worry about it. The disorder strikes adolescents primarily but can occur in younger children and adults. Kleine levin syndrome research archives hypersomnia. Abd elnabya, m find, read and cite all the research you need. There has been speculation about whether the illnesses ought to be counted as variants of each other an. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent. Samenvatting het syndroom van kleinelevin is een zeldzame neuropsychiatrische aandoening. Kleinelevin syndrome kls is a rare disorder with symptoms that include periodic hypersomnia, cognitive. This report describes an adolescent female with severe and chronic kls, focusing on clinical aspects, polysomnography, multiple sleep.

Clinical and polysomnographic features of kleinelevin syndrome. Learn about kleinelevin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day. Kls kleinelevin syndrome, rem sleep rapid eye movement sleep. Pdf kleinelevin syndrome kls is a rare disorder with symptoms that include periodic hypersomnia, cognitive and behavioural disturbances. It is a lifealtering illness which is widely misunderstood and frequently misdiagnosed as a psychological illness. Kleine levin syndrome is a rare disorder which affects mainly male teens. Kleinelevine syndrome cooccuring with bipolar disorder.

Kleine levin syndrome kls is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality. It occurs in two forms, distinguished by age of onset and other characteristics. Kleine levin syndrome is rare, affecting an estimated 15 per million individuals. Antibiotic may decrease eds in gabarelated hypersomnia. In dsmiv 9 the condition is covered by dyssomnianos while astheicdi0 10 classifies this condition in the chapter vi in diseases ofthe nervous system. In my 1993 publication abnormal fluctuations of acetylcholine and serotonin medical hypotheses vol. We report a clinically typical cas e in which the brain spect showed right frontal hypoperfusion. All funds go directly to support kls foundation projects.

Kleine levin syndrome aka also known as critchleys. This site is like a library, you could find million book here by using search box in the. Levin syndrome kls is a rare disorder of unknown cause, affecting mainly male adolescents. Associated symptoms include an abnormally uninhibited sex drive, irritability, and disorientation. A variant of the kleinelevin syndrome following head trauma article pdf available in behavioural neurology 112. Kleinelevin syndrome kls is a rare neurological disorder which affects roughly 2000 known sufferers worldwide. The icd10cm alphabetical index is designed to allow medical coders to look up various medical terms and connect them with the appropriate icd codes. Autosomal dominant polycystic kidney disease adpkd. Outlines changes in kls diagnosis criteria differential diagnosis long episodes brain functional imaging. Kleinelevin syndrome kls also called sleeping beauty syndrome, is a rare sleep disorder with onset in early adolescence.

My son and kleinelevin syndrome the sleeping beauty syndrome i patient 18052016 19. Kleinelevin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. Some boys are also found to suffer from hypersexuality in. Steinleventhal syndrome definition of steinleventhal. Kleinelevin syndrome update in 2015 kls foundation. The sleep disorders kleinelevin syndrome kls and narcolepsy have several similarities. Palm beach gardens teen has rare disorder that makes him sleep for weeks duration.

This study is a retrospective study including 15 kls patients of the past 19 years. Kleinelevin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. Omaha ne sleep specialist doctors kleinelevin syndrome. Therapeutic and diagnostic studies have the lowest evidence level. Kleinelevin syndrome kls is characterized by recurrent hypersomnia, usually starting in the second decade of life, and is associated with hyperphagia 14. In 1936, max levin added a series of five other cases, focusing on the relationship between hypersomnia and disturbed eating. Kleinelevin syndrome does not affect me or a close family member. Kleinelevin syndrome is a rare syndrome affecting roughly people worldwide the disorder typically affects male adolescents but can occur in young children and adults. These serious episodes alternate with periods without any symptoms, and normal sleep and behavior typically lasting. Wilt u dit document printen dan kunt u hier een pdfversie downloaden. Kleine levin syndrome kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world. Concurrence of immune thrombocytopenic purpura and kleinelevin syndrome supports the role of autoimmunity as the proposed pathophysiological mechanism of kleinelevin syndrome. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality.

Pdf a variant of the kleinelevin syndrome following. Willi kleine described a series of nine cases of recurrent hypersomnia in 1925. There are 0 terms under the parent term klein levin syndrome in the icd10cm alphabetical index. Each episode is of brief duration varying from a week to 12 months and affected people are entirely. It is a disease predominantly of teenagers, and boys are four times more likely to be affected than girls. Kleinelevin syndrome kls is a rare and complex form of neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, as well as a reduced understanding of the world. The relationship between the two syndromes, the praderwilli syndrome and the kleinesyndrome, deserves further study. In some cases, this means up to 20 hours a day are spent sleeping. Common symptoms are episodes of hypersomnolence, behavioral and cognitive disturbances including specific feelings of derealization, hyperphagia and hypersexuality. Kleinelevin syndrome was first described by kleine in 1925 and elaborated on by levin in 1936, but it was critchley and hoffman who further defined the syndrome in 1942 and gave it its eponym. Omaha nebraska sleep specialist doctors physician directory learn about kleinelevin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day. Characterized by periods of ravenous appetite alternating with prolonged sleep, as long as 18 hours, along with behavioral disturbances, impaired thought processes, and hallucinations.

It is characterized by recurring but reversible periods of excessive sleep up to 20 hours per day. Kleinelevin syndrome kls is a rare sleep disorder characterized by recurrent and unusually long episodes of hypersomnia, associated with behavioralcognitive disturbances, megaphagia and more rarely sexual disinhibition. The kleinelevin syndrome foundation kls foundation provides information and support to patients and families affected by kleinelevin syndrome kls. Het kleinelevin syndroom is een zeldzame aandoening. Kleine levin syndrome a rare form of periodic hypersomnia associated with hyperphagia occurring in males between 10 to 25 years old.

Kls support uk helping families affected by kleinelevin. Affected individuals may sleep for up to 20 hours per day during an episode. Kleinelevin syndrome is an infrequent disorder of uncertain aetiopathogenesis that usually affects adolescent males, producing drowsiness and alterations in behaviour, appetite and sexuality. The disorder affects mainly adolescents, although it may occur in younger children as well as adults. Pdf 537wfn151150miscellaneous topics 1isolated spinal neurofibromatosis in nf1.

Kleinelevine syndrome kls is characterized by recurrent episodes of excessive sleepiness that last from 2 days to 4 weeks, with at least annual recurrence. An autoimmune hypothesis based on clinical and genetic analyses article pdf available in neurology 5911. This syndrome may easily be confused for other neurological, metabolical or psychiatric disease. July 28, 2015 in all hypersomnias, clarithromycin, idiopathic hypersomnia, journal article summaries, kleinelevin syndrome, narcolepsy, other hypersomnias, treatments. Kleinelevin syndrome kls is a very uncommon sleep disorder. Most of the published studies have included only small numbers of patients. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral. Kleinelevin syndrome affects just 10 people in australia. First and foremost, both typically first impact young people in the form of hypersomnia, that is, overwhelming sleepiness with sleep attacks. In addition to sleepiness, individuals also have compulsive overeating and hypersexuality in primary hypersomnia, the excessive sleepiness happens over a period of many months, or sometimes, even for many years. It is rare for patients over the age of 30 years to present with their first. Since 1962, when critchley and hoffman coined the term kleinelevin syndrome kls for the triad of hypersomnia, excessive eating and often abnormal behavior which they have observed in 11 adolescent boys, the number of patients recognized with this rare syndrome expanded, the spectrum of the clinical presentation, disease course, prognosis, gender specificity and the presence of.